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- Title
A framework for understanding sources of bias in medication adherence research.
- Authors
Sinnappah, Klarissa A.; Hughes, Dyfrig A.; Stocker, Sophie L.; Vrijens, Bernard; Aronson, Jeffrey K.; Wright, Daniel F. B.
- Abstract
The sources of bias in medication adherence research have not been comprehensively explored. We aimed to identify biases expected to affect adherence research and to develop a framework for mapping these onto the phases of adherence (initiation, implementation and discontinuation). A literature search was conducted, key papers were reviewed and a Catalogue of Bias was consulted. The specific biases related to adherence measurement and metrics were mapped onto the phases of adherence using a tabular matrix. Twenty‐three biases were identified, of which 11 were specifically relevant to adherence measures and metrics. The mapping framework showed differences in the numbers and types of biases associated with each measure and metric while highlighting those common to many adherence study designs (e.g., unacceptability bias and apprehension bias). The framework will inform the design of adherence studies and the development of risk of bias tools for adherence research.
- Subjects
PATIENT compliance; EXPERIMENTAL design
- Publication
British Journal of Clinical Pharmacology, 2023, Vol 89, Issue 11, p3444
- ISSN
0306-5251
- Publication type
Article
- DOI
10.1111/bcp.15863