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- Title
Endogenous control of inflammatory visceral pain by T cell‐derived opioids in IL‐10‐deficient mice.
- Authors
Basso, Lilian; Benamar, Mehdi; Mas‐Orea, Xavier; Deraison, Céline; Blanpied, Catherine; Cenac, Nicolas; Saoudi, Abdelhadi; Dietrich, Gilles
- Abstract
Background: The opioid‐mediated analgesic activity of mucosal CD4+ T lymphocytes in colitis has been reported in immunocompetent mice so far. Here, we investigated whether CD4+ T lymphocytes alleviate from inflammation‐induced abdominal pain in mice with defective immune regulation. Methods: Endogenous control of visceral pain by opioids locally produced in inflamed mucosa was assessed in IL‐10‐deficient mice. Key Results: CD4+ T lymphocytes but not F4/80+ macrophages isolated from the lamina propria of IL‐10‐deficient mice with colitis express enkephalin‐containing opioid peptides as assessed by cytofluorometry. Colitis in IL‐10−/− mice was not associated with abdominal pain. Intraperitoneal injection of naloxone‐methiodide, a peripheral opioid receptor antagonist, induced abdominal hypersensitivity in IL‐10−/− mice with colitis. Conclusion and inferences: Opioid‐mediated analgesic activity of mucosal T lymphocytes remains operating in IL‐10−/− mice with impaired immune regulation. The data suggest that endogenous T cell‐derived opioids might reduce inflammation‐induced abdominal pain in inflammatory bowel diseases associated with homozygous "loss of function mutations" in interleukin‐10.
- Subjects
VISCERAL pain; INFLAMMATORY bowel diseases; OPIOID peptides; T cells; OPIOID receptors; MICE
- Publication
Neurogastroenterology & Motility, 2020, Vol 32, Issue 2, pN.PAG
- ISSN
1350-1925
- Publication type
Article
- DOI
10.1111/nmo.13743