We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Obesity and risk of infections: results from men and women in the Swedish National March Cohort.
- Authors
Ghilotti, Francesca; Bellocco, Rino; Ye, Weimin; Adami, Hans-Olov; Lagerros, Ylva Trolle; Trolle Lagerros, Ylva
- Abstract
<bold>Background: </bold>Previous studies have shown an association between body mass index (BMI) and infections, but the literature on type-specific community acquired infections is still limited.<bold>Methods: </bold>We included 39 163 Swedish adults who completed a questionnaire in September 1997 and were followed through record-linkages until December 2016. Information on BMI was self-reported and infections were identified from the Swedish National Patient Register using International Classification of Diseases (ICD), Tenth Revision (ICD-10) codes. We fitted multivariable Cox proportional hazards models for time-to-first-event analysis, and we used extensions of the standard Cox model when repeated events were included.<bold>Results: </bold>During a 19-year follow-up 32% of the subjects had at least one infection requiring health care contact, leading to a total of 27 675 events. We found an increased incidence of any infection in obese women [hazard ratio (HR) = 1.22; 95% confidence interval (CI) = 1.12; 1.33] and obese men (HR = 1.25; 95% CI = 1.09; 1.43) compared with normal weight subjects. For specific infections, higher incidences were observed for skin infections in both genders (HR = 1.76; 95% CI = 1.47; 2.12 for obese females and HR = 1.74; 95% CI = 1.33; 2.28 for obese males) and gastrointestinal tract infections (HR = 1.44; 95% CI = 1.19; 1.75), urinary tract infections (HR = 1.30; 95% CI = 1.08; 1.55) and sepsis (HR = 2.09; 95% CI = 1.46; 2.99) in obese females. When accounting for repeated events, estimates similar to the aforementioned ones were found.<bold>Conclusions: </bold>Obesity was associated with an increased risk of infections in both genders. Results from multiple-failure survival analysis were consistent with those from classic Cox models.
- Subjects
SWEDEN; PROPORTIONAL hazards models; BODY mass index; SKIN infections; COMMUNICABLE disease epidemiology; COMPARATIVE studies; GASTROINTESTINAL diseases; LEANNESS; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; OBESITY; RESEARCH; SEPSIS; SEX distribution; SKIN diseases; URINARY tract infections; EVALUATION research; DISEASE incidence
- Publication
International Journal of Epidemiology, 2019, Vol 48, Issue 6, p1783
- ISSN
0300-5771
- Publication type
journal article
- DOI
10.1093/ije/dyz129