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- Title
Gene-level quantitative trait mapping in Caenorhabditis elegans.
- Authors
Noble, Luke M.; Rockman, Matthew V.; Teotónio, Henrique
- Abstract
The Caenorhabditis elegans multiparental experimental evolution (CeMEE) panel is a collection of genome-sequenced, cryopreserved recombinant inbred lines useful for mapping the evolution and genetic basis of quantitative traits. We have expanded the resource with new lines and new populations, and here report the genotype and haplotype composition of CeMEE version 2, including a large set of putative de novo mutations, and updated additive and epistatic mapping simulations. Additive quantitative trait loci explaining 4% of trait variance are detected with >80% power, and the median detection interval approaches single-gene resolution on the highly recombinant chromosome arms. Although CeMEE populations are derived from a long-term evolution experiment, genetic structure is dominated by variation present in the ancestral population
- Subjects
CAENORHABDITIS elegans; LONG-Term Evolution (Telecommunications); HAPLOTYPES; GENE mapping; CHROMOSOMES
- Publication
G3: Genes | Genomes | Genetics, 2021, Vol 11, Issue 2, p1
- ISSN
2160-1836
- Publication type
Article
- DOI
10.1093/g3journal/jkaa061