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- Title
Ultraconserved Non-coding DNA within Diptera and Hymenoptera.
- Authors
Brody, Thomas; Yavatkar, Amarendra; Kuzin, Alexander; Odenwald, Ward F.
- Abstract
This study has taken advantage of the availability of the assembled genomic sequence of flies, mosquitos, ants and bees to explore the presence of ultraconserved sequence elements in these phylogenetic groups. We compared non-coding sequences found within and flanking Drosophila developmental genes to homologous sequences in Ceratitis capitata and Musca domestica. Many of the conserved sequence blocks (CSBs) that constitute Drosophila cis-regulatory DNA, recognized by EvoPrinter alignment protocols, are also conserved in Ceratitis and Musca. Also conserved is the position but not necessarily the orientation of many of these ultraconserved CSBs (uCSBs) with respect to flanking genes. Using the mosquito EvoPrint algorithm, we have also identified uCSBs shared among distantly related mosquito species. Side by side comparison of bee and ant EvoPrints of selected developmental genes identify uCSBs shared between these two Hymenoptera, as well as less conserved CSBs in either one or the other taxon but not in both. Analysis of uCSBs in these dipterans and Hymenoptera will lead to a greater understanding of their evolutionary origin and function of their conserved non-coding sequences and aid in discovery of core elements of enhancers.
- Subjects
NON-coding DNA; DIPTERA; HOUSEFLY; MEDITERRANEAN fruit-fly; GENE enhancers; BEES; MOSQUITOES; HYMENOPTERA
- Publication
G3: Genes | Genomes | Genetics, 2020, Vol 10, Issue 9, p1
- ISSN
2160-1836
- Publication type
Article
- DOI
10.1534/g3.120.401502