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- Title
New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability.
- Authors
Kirk, Joseph A.; Gebhart, Dana; Buckley, Anthony M.; Lok, Stephen; Scholl, Dean; Douce, Gillian R.; Govoni, Gregory R.; Fagan, Robert P.
- Abstract
The article discusses a study that described a precision bactericidal agent, Av-CD291.2, which kills specific Clostridium difficile strains and prevents them from colonizing mice. Topics covered include how the antimicrobial redefines the role of C. difficile S-layer in virulence and viability, the roles for S-layer protein A (SlpA) in sporulation, resistance to innate immunity effectors and toxin production uncovered by the characterization of the mutants, and its therapeutic potential.
- Subjects
ANTIBACTERIAL agents; CLOSTRIDIOIDES difficile; VIRULENCE of bacteria; MICROBIAL viability counts; BACTERIAL sporulation; NATURAL immunity; THERAPEUTICS
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 406, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aah6813