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- Title
Ultrasound-Mediated Ocular Drug Delivery: From Physics and Instrumentation to Future Directions.
- Authors
Duncan, Blair; Al-Kassas, Raida; Zhang, Guangming; Hughes, Dave; Qiu, Yongqiang
- Abstract
Drug delivery to the anterior and posterior segments of the eye is impeded by anatomical and physiological barriers. Increasingly, the bioeffects produced by ultrasound are being proven effective for mitigating the impact of these barriers on ocular drug delivery, though there does not appear to be a consensus on the most appropriate system configuration and operating parameters for this application. In this review, the fundamental aspects of ultrasound physics most pertinent to drug delivery are presented; the primary phenomena responsible for increased drug delivery efficacy under ultrasound sonication are discussed; an overview of common ocular drug administration routes and the associated ocular barriers is also given before reviewing the current state of the art of ultrasound-mediated ocular drug delivery and its potential future directions.
- Subjects
OPHTHALMIC drugs; INTRAOCULAR drug administration; POSTERIOR segment (Eye); ANTERIOR eye segment; DRUG administration routes; DRUG efficacy
- Publication
Micromachines, 2023, Vol 14, Issue 8, p1575
- ISSN
2072-666X
- Publication type
Article
- DOI
10.3390/mi14081575