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- Title
Predictive effect of the decline in CD4<sup>+</sup> T cell levels in blood on infection in patients with severe hemorrhagic stroke and mechanism.
- Authors
Yating Wang; Junshuang Guo; Fan Yang; Ruirui Dong; Dandan Song; Peipei Huang; Lijun Wen; Guoliang Xiang; Shuiyu Wang; Junfang Teng; Wang Miao
- Abstract
Objective: The purpose of this research was to evaluate the influence of immunity on infection in patients with severe hemorrhagic stroke and explore the mechanism underlying this connection. Methods: Clinical data obtained from126 patients with severe hemorrhagic stroke were retrospectively analyzed, and the factors affecting infection were screened by multivariable logistic regression models. Nomograms, calibration curves, the Hosmer-Lemeshow goodness-of-fit test, and decision curve analysis were used to examine the effectiveness of themodels in evaluating infection. Themechanism underlying the reduction in CD4+ T-cell levels in blood was explored by analysis of lymphocyte subsets and cytokines in cerebrospinal fluid (CSF) and blood. Results: The results showed that CD4+ T-cell levels of <300/µL was an independent risk factor for early infection. The models for multivariable logistic regression involving the CD4+ T-cell levels and other influencing factors had good applicability and effectiveness in evaluating early infection. CD4+ T-cell levels decreased in blood but increased in CSF. Similarly, interleukin (IL)-6 and IL-8 levels in CSF had a significant increase, generating a substantial concentration gradient between the CSF and the blood. Conclusion: Reduced blood CD4+ T-cell counts among patients who had severe hemorrhagic stroke increased the risk of early infection. CSF IL-6 and IL-8 may be involved in inducing the migration of CD4+ T cells into the CSF and decreasing blood CD4+ T-cell levels.
- Subjects
HEMORRHAGIC stroke; T cells; BLOOD cells; CEREBROSPINAL fluid; LYMPHOCYTE subsets
- Publication
Frontiers in Neurology, 2023, p1
- ISSN
1664-2295
- Publication type
Article
- DOI
10.3389/fneur.2023.1118282