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- Title
Telomere Architecture Correlates with Aggressiveness in Multiple Myeloma.
- Authors
Rangel-Pozzo, Aline; Yu, Pak Lok Ivan; LaL, Sadhana; Asbaghi, Yasmin; Sisdelli, Luiza; Tammur, Pille; Tamm, Anu; Punab, Mari; Klewes, Ludger; Louis, Sherif; Knecht, Hans; Olujohungbe, Adebayo; Mai, Sabine; Mikala, Gabor
- Abstract
Simple Summary: Multiple myeloma (MM) remains an incurable blood cancer. One of the current challenges in patient management is the risk assessment and subsequent treatment management for each patient with MM. Patients with an identical diagnosis may present very different disease courses and outcomes. This challenge of MM is a current focus of the scientific and medical communities. In our research, we have used an imaging approach to determine the risk of MM patients to progressive/aggressive disease. Using three-dimensional (3D) imaging of telomeres, the ends of chromosomes, we report that specific telomeric profiles are associated with aggressive disease. The prognosis of multiple myeloma (MM), an incurable B-cell malignancy, has significantly improved through the introduction of novel therapeutic modalities. Myeloma prognosis is essentially determined by cytogenetics, both at diagnosis and at disease progression. However, for a large cohort of patients, cytogenetic analysis is not always available. In addition, myeloma patients with favorable cytogenetics can display an aggressive clinical course. Therefore, it is necessary to develop additional prognostic and predictive markers for this disease to allow for patient risk stratification and personalized clinical decision-making. Genomic instability is a prominent characteristic in MM, and we have previously shown that the three-dimensional (3D) nuclear organization of telomeres is a marker of both genomic instability and genetic heterogeneity in myeloma. In this study, we compared in a longitudinal prospective study blindly the 3D telomeric profiles from bone marrow samples of 214 initially treatment-naïve patients with either monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), or MM, with a minimum follow-up of 5 years. Here, we report distinctive 3D telomeric profiles correlating with disease aggressiveness and patient response to treatment in MM patients, and also distinctive 3D telomeric profiles for disease progression in smoldering multiple myeloma patients. In particular, lower average intensity (telomere length, below 13,500 arbitrary units) and increased number of telomere aggregates are associated with shorter survival and could be used as a prognostic factor to identify high-risk SMM and MM patients.
- Subjects
TELOMERES; DISEASE progression; GENETIC mutation; RISK assessment; MONOCLONAL gammopathies; MULTIPLE myeloma; BONE marrow; LONGITUDINAL method; DISEASE risk factors
- Publication
Cancers, 2021, Vol 13, Issue 8, p1969
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers13081969