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- Title
Relationship between plasma homocystein levels and polyneuropaty in patients using levodopa for idopathic Parkinson's disease.
- Authors
Bedir, Mithat; Acar, Hürtan; Özer, Feriha; Atmaca, Birgül Kursun; Mutlu, Aytül; Genç, Fazil; Özben, Serkan; Koldas, Macit; Aydemir, Tugba Özcan; Petek, Belgian Balci
- Abstract
Objective: Recent studies showed high plasma homocysteine levels in patients treated with Levodopa for Parkinson's disease (PD). Homocysteine, due to its exotoxic effect, might be the cause of polyneuropathy seen in PD. In this study, our aim was to show the correlation between high concentration of plasma homocysteine levels and polyneuropathy associated with PD. Material and Methods: Forty-one patients with PD receiving levodopa treatment (patient group) and 30 healthy subjects (control group) were included in this study. We compared the two groups in terms of electrophysiological findings. Twelve patients had high plasma homocysteine levels and 29 of them had low plasma homocysteine levels. Results: Six of the 41 patients had sensorial polyneuropathy and decreased compound muscle action potantiel amplitude compared to controls. Two patients had high plasma homocysteine levels, two patients had nearly high plasma homocysteine levels, two patients had low plasma homocysteine levels who had sensorial polyneuropathy. Conclusion: Although in our study, we did not show any correlation between polyneuropathy and high plasma homocysteine levels, further studies including homogeneous groups of younger patients with PD are needed.
- Publication
Medical Bulletin of Haseki / Haseki Tip Bulteni, 2012, Vol 50, Issue 2, p53
- ISSN
1302-0072
- Publication type
Journal Article