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- Title
Is There any Role for Granulocyte Colony Stimulating Factor in Improvement of Implantation in Intrauterine Insemination? A Prospective Double-Blind Randomized Control Trial.
- Authors
Amooee, Sedigheh; Shomali, Zahra; Namazi, Niloofar; Jannati, Fatemeh
- Abstract
Background: Granulocyte colony stimulating factor (GCSF) has been introduced as an immunomodulatory agent by increasing implantation rate in vitro fertilization (IVF) patients but it has not been studied in intrauterine insemination (IUI) patients. The aim of this study is to answer the role of GCSF in implantation rate of IUI. Materials and methods: In this prospective double-blind randomized control trial, 320 eligible patients were enrolled, who were referred to the referral infertility clinic of Shiraz University of Medical Sciences from February 2018 till the end of 2019. They were divided into two groups randomly. After collecting the demographic data, all patients received clomiphene citrate from the 5th day of the menstruation cycle for 5 days. 50-150 units of recombinant purified follicle-stimulating factor (FSH) were started from the 8th day of the cycle. Follicle monitoring was done by trans-vaginal sonography till a mature follicle of 18 mm or more was developed. Human chorionic gonadotropin (HCG) injection was done in both groups with intrauterine administration of 300 μg GCSF in the case group and normal saline in the control group simultaneously. After 36 hours, IUI was performed. The clinical pregnancy, miscarriage, and ongoing pregnancy rates of both groups were calculated by SPSS software. Results: The results showed improvement of clinical pregnancy rate [15.38% vs. 13.81% OR=1.17 (0.62-2.21)], miscarriage rate [3.84% vs. 5.26% OR=0.74 (0.25-2.20)] and ongoing pregnancy rate [11.53% vs. 8.55% OR=1.37 (0.65-2.92)] in the GCSF group compared to the control. However, the results revealed no statistically significance (P>0.05). Conclusion: Although it was not statistically significant, 300 μg Intrauterine GCSF administration simultaneously with hCG injection in standard IUI procedure might increase the pregnancy outcomes. Further studies are warranted (registration number: IRCT201212079281N2).
- Subjects
IRAN; RISK factors in miscarriages; CLOMIPHENE; GRANULOCYTE-colony stimulating factor; FOLLICLE-stimulating hormone; ENDOSCOPIC ultrasonography; RANDOMIZED controlled trials; HUMAN artificial insemination; BLIND experiment; STATISTICAL sampling; INDUCED ovulation; LONGITUDINAL method; RECOMBINANT proteins; CHORIONIC gonadotropins
- Publication
International Journal of Fertility & Sterility, 2022, Vol 16, Issue 4, p281
- ISSN
2008-076X
- Publication type
Article
- DOI
10.22074/IJFS.2021.537125.1171