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- Title
Haemodynamics using transthoracic echocardiography in healthy pregnant and non-pregnant baboons ( Papio hamadryas).
- Authors
Dennis, Alicia T.; Castro, Julian M.; Heffernan, Scott; Hennessy, Annemarie
- Abstract
Background To determine systolic and diastolic function using transthoracic echocardiography in the baboon ( Papio hamadryas). Methods Transthoracic echocardiography was performed in eight non-pregnant female and six pregnant baboons according to American Society of Echocardiography recommendations. Results Haemodynamic measurements were obtained from fourteen baboons. Compared to non-pregnant baboons, pregnant baboons demonstrated: (mean ± SD, pregnant vs. healthy) increased cardiac output (1615 ± 121 ml/minutes vs. 1317 ± 134 ml/minutes P = 0.001) due to an increased heart rate [120 ± 11 beats per minute (BPM) vs. 105 ± 6 BPM P = 0.018]. The inter-observer and intra-observer variability (mean difference ± SD) for the left ventricular outflow tract diameter was 0.05 ± 0.07 cm and 0.01 ± 0.03 cm respectively. There was minimal impact to the animal's daily activities. Conclusions Transthoracic echocardiography was applicable and reproducible for the assessment of haemodynamics in baboons thus enabling translation of animal results to human studies.
- Subjects
HAMADRYAS baboon; HEMODYNAMICS; ECHOCARDIOGRAPHY; CARDIAC output; HEART rate monitoring; BABOONS as laboratory animals; SCIENTIFIC observation
- Publication
Journal of Medical Primatology, 2012, Vol 41, Issue 2, p122
- ISSN
0047-2565
- Publication type
Article
- DOI
10.1111/j.1600-0684.2011.00532.x