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- Title
Behavioral tests as indicator for pain and distress in a primate endometriosis model.
- Authors
Arnold, C.; Lamp, J.; Lamp, O.; Einspanier, A.
- Abstract
Background As common marmosets (Callithrix jacchus) are frequently used experimental animals, sensitive test systems are needed to evaluate impairment and pain caused by procedures and diseases. Methods A diurnal profile of healthy animals was obtained by videotaping. Differences in social behavior and cognitive skills between marmosets with established endometriosis and healthy monkeys were investigated using the videotaping, the Wisconsin General Test Apparatus (WGTA), and a food tree. Results The marmosets showed a mostly trimodal course of activity. Social grooming and activity were significantly decreased in animals with endometriosis; furthermore, the diseased monkeys habituated significantly worse to the cognitive test settings. The food tree experiments offered no differences between diseased and control animals. Conclusion The videotaping and the WGTA are suitable methods to detect disease-related impairments in common marmosets, which is essential for the refinement of experiments.
- Subjects
ENDOMETRIOSIS; PSYCHOLOGICAL distress; CALLITHRIX jacchus; PAIN in animals; VIDEO recording; MARMOSET behavior; COGNITIVE testing; DISEASES
- Publication
Journal of Medical Primatology, 2011, Vol 40, Issue 5, p317
- ISSN
0047-2565
- Publication type
Article
- DOI
10.1111/j.1600-0684.2011.00496.x