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- Title
Multiphenotypic Lymphoma with Rearrangements of the T Cell Receptor Beta Chain and Gamma Chain Genes.
- Authors
Yasukawa, Masaki; Kanemitsu, Nozomu; Inatsuki, Akira; Mise, Haruo; Iwamasa, Kikue; Fujita, Shigeru
- Abstract
A case of chemotherapy-resistant non-Hodgkin's lymphoma simultaneously expressing T cell (CD7)-, B cell (CD19)- and myeloid (CD13, CD33)-associated surface antigens is presented. Cytochemical analysis revealed that the lymphoma cells were positive for terminal deoxynucleotidyl transferase, but negative for myeloperoxidase and esterase. Rearrangements of both the T cell receptor β chain and γ chain genes were observed, but the immunoglobulin genes showed a germ line configuration. The rearrangement was not detected within the breakpoint cluster region on chromosome 22. These findings are considered to represent aberrant expressions of the B cell- and myeloid-associated antigens in early-stage T cell lineage lymphoma cells. Copyright © 1989 S. Karger AG, Basel
- Publication
Acta Haematologica, 1989, Vol 81, Issue 3, p143
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000205547