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- Title
A comparison of the effectiveness of lipid-lowering therapy between HIV- and non-HIV-infected subjects with hyperlipidaemia.
- Authors
Townsend, Mary L.; Hollowell, Stephanie B.; Bhalodia, Jasmin; Wilson, Kenneth H.; Kaye, Keith S.; Johnson, Melissa D.
- Abstract
This retrospective cohort study conducted at the Durham Veterans Affairs Medical Center evaluated the effectiveness and safety of lipid-lowering therapy (LLT) in a HIV-infected population as compared with a general population with hyperlipidaemia. Fifty-three HIV-infected subjects who developed dyslipidaemia and 53 age-matched non-HIV-infected subjects receiving LLT were selected. Efficacy of LLT was assessed after three and six months. Non-HIV-infected subjects were more likely to achieve total cholesterol (TC) goals at three and six months (P = 0.045, P = 0.005) and triglyceride (TG) goals at six months (P = 0.017). Less than 45% of HIV-infected subjects met National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) goals at three or six months. While non-HIV-infected subjects were more likely to achieve TC and TG goals than HIV-infected subjects, overall achievement of NCEP III goals was poor. This result was likely due to treatment with inappropriately low doses of statins.
- Subjects
DURHAM (N.C.); NORTH Carolina; HIV infections; HIV-positive persons; HIV; HYPERLIPIDEMIA; LIPID metabolism disorders; MEDICAL centers; VETERANS' hospitals
- Publication
International Journal of STD & AIDS, 2007, Vol 18, Issue 12, p851
- ISSN
0956-4624
- Publication type
Article
- DOI
10.1258/095646207782716974