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- Title
Effects of Electroconvulsive Therapy on Frontal White Matter in Late-Life Depression: A Diffusion Tensor Imaging Study.
- Authors
Nobuhara, K.; Okugawa, G.; Minami, T.; Takase, K.; Yoshida, T.; Yagyu, T.; Tajika, A.; Sugimoto, T.; Tamagaki, C.; Ikeda, K.; Sawada, S.; Kinoshita, T.
- Abstract
This study was conducted to elucidate the effects of electroconvulsive therapy (ECT) on frontal white matter in late-life depressed patients. Diffusion tensor imaging was performed on 8 late-life depressed patients and 12 healthy age-matched controls. The patients were scanned before and after a course of ECT. Fractional anisotropy (FA) was determined in the frontal and temporal regions and the corpus callosum. A significant white matter FA reduction was found in widespread frontal and temporal brain regions in patients with depression before ECT treatment compared with controls. A significant increase in frontal white matter FA was seen following ECT treatment. A course of bilateral ECT ameliorated white matter integrity in frontal brain regions. This suggests a strong relationship with the antidepressant action of ECT. Copyright © 2004 S. Karger AG, Basel
- Subjects
ELECTROCONVULSIVE therapy; MENTAL depression; FRONTAL lobe; MAGNETIC resonance imaging; SHOCK therapy; AFFECTIVE disorders
- Publication
Neuropsychobiology, 2004, Vol 50, Issue 1, p48
- ISSN
0302-282X
- Publication type
Article
- DOI
10.1159/000077941