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- Title
Synthesis of 3‐Acyl‐Isoxazoles via Radical 5‐endo trig Cyclization of β,γ‐Unsaturated Ketones with NaNO<sub>2</sub>.
- Authors
Jiang, Ping; Wang, Yaming; Chen, Dengfeng; Zheng, Yu; Huang, Shenlin
- Abstract
Here we report a facile cyclization reaction of β,γ‐unsaturated ketones with NaNO2 under mild conditions to construct 3‐acyl‐isoxazoles. This transformation is realized via nitrosation of the activated methylene, radical 5‐endo trig cyclization, and then aromatization, according to some control experiments. Further, this protocol provided an efficient access to a variety of isoxazoles from readily available allyl ketones.
- Subjects
RING formation (Chemistry); KETONES; ISOXAZOLES; NITROSATION; AROMATIZATION
- Publication
European Journal of Organic Chemistry, 2022, Vol 2022, Issue 2, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202101411