We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Perioperative Docetaxel, Oxaliplatin, Fluorouracil, and Leucovorin (FLOT) in Patients with Gastric or Esophagogastric Junction Adenocarcinoma; Real-Life Experience.
- Authors
YILDIZ, Fatih; ERASLAN, Emrah; ILHAN, Aysegul; DEMIR, Hacer; DEMIR, Nazan; ERDUR, Erkan; YILDIRIM, Ozgen Ahmet; KANMAZ, Huseyin; ASLAN, Ferit; TUFAN, Gulnihal; DURNALI, Ayse; OKSUZOGLU, Berna; DEMIRCI, Umut
- Abstract
In patients with gastic cancer, five-year survival is poor in the locally advanced stage. Docetaxel, oxaliplatin, leucovorin, and 5-fluorouracil (FLOT) combination regimen has been shown to provide a survival advantage in the locally advanced stage. In this study, we aimed to evaluate the efficacy and tolerability of FLOT with real-life data in patients with locally advanced gastric/esophagogastric junction cancers. This retrospective study was conducted between June 2016 - March 2020 and included 106 patients' data from six centers in Turkey. Median age was 60 (33-82). Primary tumor localization was stomach in 76 (71.7%) patients. Seventy-six (71.7%) patients were operated after median 4 (1-8 cycles) cycles of preoperative FLOT. Pathological complete regression (pCR)was obtained in 10 (13.1%) of the operated patients. Median follow-up was 9.1 (1.4-45.7) months. One-year DFS was 63.2% and the two-year OS was 65.1%. Three (2.8%) patients had chemotherapy-related deaths. Due to chemotherapy-related toxicity and intoleration, 19 (17.9%) patients had dose reduction. The pCR obtained by FLOT appears higher than other regimens. This study is one of the rare multicentric real-life data showing the efficacy and tolerability of the FLOT regimen in the perioperative treatment in GC and EJC.
- Subjects
TURKEY; ESOPHAGOGASTRIC junction; ESOPHAGOGASTRIC junction cancer; DOCETAXEL; OXALIPLATIN; FOLINIC acid
- Publication
UHOD: International Journal of Hematology & Oncology / Uluslararasi Hematoloji Onkoloji Dergisi, 2020, Vol 30, Issue 3, p155
- ISSN
1306-133X
- Publication type
Article
- DOI
10.4999/uhod.204238