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- Title
PERSONALISED THERAPY OF BREAST CANCER -- SIGNALLING PATHWAYS AND TARGETED THERAPY OF BREAST CANCER.
- Authors
Beketić-Orešković, Lidja
- Abstract
Personalised therapy of breast cancer is the optimal therapeutic approach to the patient, taking into consideration his personal characteristics, as well as clinical characteristics of the malignant disease, involving pathohistological and molecular abnormalities of certain tumour. With the development of molecular oncology methods, genetic profiling of each individual tumor is possible. Beside the major subtypes of breast carcinoma based on steroide receptors, Ki-67 proliferative index, and HER-2 receptors, numerous genetic subtypes of breast cancer have been found due to enormous genetic heterogeneity and instability of tumor cells. Some of genetic changes are considered as "driving" genes, resulting in dysregulations of crucial signalling transduction pathways involving in cell proliferation, angiogenesis, apoptosis, invasion or metastasis. Certain components of signalling transduction pathways can be targeted molecules of the so-called targeted biological therapy. Proper understanding of complexities of these dysregulated multiple intracellular signalling cascades in tumor cells is essential for the development of novel potential molecular therapeutic targets.
- Subjects
INDIVIDUALIZED medicine; BREAST cancer treatment; TUMORS; ONCOLOGY research; BIOTHERAPY; CELLULAR signal transduction
- Publication
Rad Hrvatske Akademije Znanosti i Umjetnosti. Medicinske Znanosti, 2014, Vol 520, Issue 40, p13
- ISSN
1330-5301
- Publication type
Article