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- Title
Temporal Changes in the Endocardial ST Segment During the Evolution of Myocardial Infarction in Dogs.
- Authors
Lessick, Jonathan; Wolf, Tamir; Gepstein, Lior; Hayam, Gal; Ben-Haim, Shlomo A.
- Abstract
Acute coronary occlusion causes ST-segment elevation on the body surface ECG and on the epicardial electrogram in the territory supplied by that artery. The occurrence and significance of endocardial ST changes have not been studied. The NOGA electromechanical mapping was performed on eight anesthetized dogs at baseline, immediately after occlusion of the LAD, and again at 5 hours to assess regional changes in the ST segment. AI 3 days and 4 weeks the ventricles were remapped for comparison. Regional unipolar ST-segment elevation was measured for each zone from NOGA maps at 0, 80, and 120 .ms after the J point. ST segments rose immediately in the infarct zones, as demarcated by echocardiography, compared to remote zones, but by 3 days had dropped below, and at 4 weeks returned to baseline values. Immediately postocclusion, ST elevation at 120 ms best differentiated between normal versus abnormal echo scores (concordance = 0.80), probably by correcting for pressure reduced ST elevation. In conclusion, acute endocardial ST-segment changes occur in the infarct zone in the dog, showing a distinctive temporal evolution.
- Subjects
ISCHEMIA; BLOOD circulation disorders; ELECTROCARDIOGRAPHY; ELECTRODIAGNOSIS; MYOCARDIAL infarction; LABORATORY dogs; HEART disease diagnosis; ELECTROPHYSIOLOGY
- Publication
Pacing & Clinical Electrophysiology, 2002, Vol 25, Issue 11, p1616
- ISSN
0147-8389
- Publication type
Article
- DOI
10.1046/j.1460-9592.2002.01616.x