We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Alternative Mechanism for PFOA?
- Authors
Hood, Ernie
- Abstract
The article discusses research conducted to evaluate the correlation between ingestion of perfluorooctanoic acid (PFOA) and liver cancer. A number of rainbow trout were fed PFOA, while others were fed the peroxisome proliferators cloribrate (CLOF) and dehydroepiandrosterone (DHEA). The incidence and multiplicity of liver tumors in the fish were studied. While the fish ingesting both PFOA and DHEA showed increased signs of hepatocarcinogenesis, CLOF did not seem to affect the liver. It was determined that PFOA is marginally estrogenic in trout and that an interference in estrogenic communication may be associated with liver cancer.
- Subjects
LIVER cancer; PERFLUOROOCTANOIC acid; ANIMAL models of carcinogenesis; CARCINOGENESIS; ENVIRONMENTALLY induced cancer; CANCER risk factors; CANCER research; CANCER endocrinology; DEHYDROEPIANDROSTERONE; PHYSIOLOGICAL effects of estrogen; XENOESTROGENS
- Publication
Environmental Health Perspectives, 2008, Vol 116, Issue 8, pA351
- ISSN
0091-6765
- Publication type
Article