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- Title
Concentrations of antioxidative trace elements - selenium and zinc - in patients with sigmoid or rectal cancers.
- Authors
Drozda, Rafał; Trzciński, Radzisław; Rutkowski, Maciej; Grzegorczyk, Krzysztof; Dziki, Łukasz; Sygut, Andrzej; Kołomecki, Krzysztof; Dziki, Adam
- Abstract
Introduction: Colorectal cancer (CRC) is one of the most common neoplasms of alimentary tract in the world. Both its diagnosis and treatment outcomes are still far from satisfactory. Therefore, different studies focusing on determination of preventive measures of the drugs have been initiated. It was found that reactive oxygen species (ROS) are one of many carcinogens in the pathogenesis of CRC, and their pathogenic effect manifests when so called antioxidative protection barrier of the organism is weakened. Two important compounds of this barrier are, among others, selenium (Se) and zinc (Zn) - antioxidative trace elements providing prevention against carcinogenesis. Aim of study: Determination of concentrations of selenium and zinc in blood plasma of patients with sigmoid and rectal cancers in comparison to the concentrations of these trace elements in healthy individuals. Material and methods: One hundred sixty consecutive patients were included into the study. Patients were divided into four groups (n=40, each): the control group, patients with adenomatous polyps of sigmoid or rectum, patients with operative adenocarcinoma of sigmoid or rectum, and those with non-operable adenocarcinoma of sigmoid or rectum. Results: Selenium and zinc concentrations determined in all groups of affected patients were significantly lower than in the control group which supports the involvement of these elements in the inhibition of carcinogenesis of CRC. Conclusions: Implementation of controlled supplementation with Se and Zn preparations may seem to be beneficial in the prevention of CRC in high-risk patients.
- Subjects
ANTIOXIDANTS; SELENIUM; ZINC; CANCER patients; RECTAL cancer; HEALTH risk assessment
- Publication
Gastroenterologia Polska / Gastroenterology, 2008, Vol 15, Issue 6, p391
- ISSN
1232-9886
- Publication type
Article