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- Title
Perinatal Plasma Monocyte Chemotactic Protein-1 Concentrations in Intrauterine Growth Restriction.
- Authors
Briana, Despina D.; Boutsikou, Maria; Baka, Stavroula; Papadopoulos, George; Gourgiotis, Dimitrios; Puchner, Karl Philipp; Hassiakos, Dimitrios; Malamitsi-Puchner, Ariadne
- Abstract
Monocyte-chemotactic protein-1 (MCP-1) plays vital roles in immune response, angiogenesis, and pregnancy outcome. We investigated plasma MCP-1 concentrations in 40 mothers and their 20 intrauterine-growth-restricted (IUGR) and 20 appropriate-for-gestational-age (AGA) fetuses and neonates on postnatal days 1 (N1) and 4 (N4). Maternal and fetal MCP-1 concentrations were decreased (P < 001 and P = .018, resp.), whereas N1 MCP-1 concentrations were elevated in IUGR group (P = .012). In both groups, fetal MCP - 1 concentrations were lower compared to N1 and N4 ones (P = .045, P = .012. resp., for AGA, P < .001 in each case for IUGR). Reduced maternal and fetal MCP-1 concentrations in IUGR may reflect failure of trophoblast invasion, suggesting that down-regulation of MCP-1 may be involved in the pathogenesis of IUGR. Increased MCP-1 concentrations in IUGR neonates and higher postnatal ones in all infants may be attributed to gradual initiation of ex utero angiogenesis, which is possibly enhanced in IUGR.
- Subjects
BLOOD plasma; FETAL development; CHEMOKINES; MONOCYTES; NEWBORN infants; NEOVASCULARIZATION
- Publication
Mediators of Inflammation, 2007, Vol 2007, Issue 2, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2007/65032