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- Title
Programmed to direct alloimmunity.
- Authors
Swaminathan, Sundararaman
- Abstract
After an allograft placement, the body faces an intricate task of mounting a balanced immune response to foreign antigens. The ideal response entails maintaining enough immunity to prevent infections and cancer yet not endangering the ability to achieve and maintain organ tolerance. Programmed death-1 and its ligands expressed on non-professional antigen-presenting cells such as the renal tubular epithelium function to downregulate allogenic T-cell responses and thus play an important role in achieving this balance.
- Subjects
HOMOGRAFTS; IMMUNE response; ANTIGENS; IMMUNITY; ANTIGEN presenting cells; CELL death
- Publication
Kidney International, 2010, Vol 78, Issue 1, p8
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2010.95