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- Title
Ischemic preconditioning produces systemic protective and adoptively transferable effects.
- Authors
Reutzel-Selke, Anja; Pratschke, Johann; Martins, Paulo N.; Denecke, Christian; Jurisch, Anke; Kotsch, Katja; Pascher, Andreas; Neuhaus, Peter; Tullius, Stefan G.
- Abstract
Ischemic preconditioning directly protects organs from subsequent non-specific injuries. To test for systemic protective effects kidneys from F-344 donor rats went through a short warm ischemic time. Both, clamped and contralateral unclamped kidneys were procured after either a short (15 min) or long (24 h) reperfusion period and transplanted into Lewis rats following a prolonged cold ischemia. To test for transferable effects serum from preconditioned rats was infused either into native donors or recipients. Following a short reperfusion interval protective effects were only evident in previously clamped grafts. However, after a long reperfusion interval protective effects were observed in previously clamped and contralateral unclamped kidneys promoting improved survival, structure, function and reduced inflammation. These effects were not related to heme oxygenase-1 induction or neural transmission as heme oxygenase-1 inhibition or denervation prior to preconditioning did not affect organ protection. These results show that renal ischemic preconditioning is associated with time-dependent local and systemically transferable protection.Kidney International (2008) 74, 622–630; doi:10.1038/ki.2008.208; published online 28 May 2008
- Subjects
ISCHEMIA; KIDNEY disease prevention; HEMOGLOBINS; SERUM; NEURAL transmission; DENERVATION
- Publication
Kidney International, 2008, Vol 74, Issue 5, p622
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2008.208