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- Title
Q fever: persistence of antigenic non-viable cell residues of Coxiella burnetii in the host—implications for post Q fever infection fatigue syndrome and other chronic sequelae.
- Authors
MARMION, B. P.; SUKOCHEVA, O.; STORM, P. A.; LOCKHART, M.; TURRA, M.; KOK, T.; AYRES, J.; ROUTLEDGE, H.; GRAVES, S.
- Abstract
Background: Our previous studies of persistence of Coxiella burnetii in humans after an initial acute Q fever infection revealed raised, maintained antibody levels and low levels of coxiella genomic DNA at the age of 5 years from onset in Australian patients and at 12 years in patients in the 1989 Birmingham UK Q fever outbreak. Attempts to isolate the coxiella in standard cell culture and susceptible mice by serial passage of PCR positive PBMC and bone marrow were negative.
- Subjects
COXIELLA burnetii; EPITOPES; Q fever; FATIGUE (Physiology); COXIELLA
- Publication
QJM: An International Journal of Medicine, 2009, Vol 102, Issue 10, p673
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcp077