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- Title
Vaccine-induced cytotoxic T lymphocytes protect against retroviral challenge.
- Authors
Hislop, Andrew D.; Good, Michael F.; Mateo, Luis; Gardner, Joy; Gatei, Magtouf H.; Daniel, Richard C.W.; Meyers, Barry V.; Lavin, Martin F.; Suhrbier, Andreas
- Abstract
The development of prophylactic vaccines against retroviral diseases has been impeded by the lack of obvious immune correlates for protection. Cytotoxic T-lymphocyte (CTL), CD4-lymphocyte, chemokine and/or antibody responses have all been associated with protection against HIV and AIDS; however, effective and safe vaccination strategies remain elusive. Here we show that vaccination with a minimal ovine CTL peptide epitope identified within gp51 of the retrovirus bovine leukemia virus (BLV), consistently induced peptide-specific CTLs. Only sheep whose CTLs were also capable of recognizing retrovirus-infected cells were fully protected when challenged with BLV. This retrovirus displays limited sequence variation; thus, in the relative absence of confounding CTL escape variants, virus-specific CTLs targeting a single epitope were able to prevent the establishment of a latent retroviral infection.
- Subjects
T cells; LEUKEMIA; VACCINATION; EPITOPES
- Publication
Nature Medicine, 1998, Vol 4, Issue 10, p1193
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/2690