We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Evaluation of Endothelin-1 and Endothelin Receptor Type A Gene Polymorphisms in Patients with Vitiligo.
- Authors
Bingül, İlknur; Aydingoz, İkbal Esen; Vural, Pervin; Doğru-Abbasoğlu, Semra; Uysal, Müjdat
- Abstract
Background: Endothelin-1 (EDN1) and EDN receptor type A (EDNRA) are implicated in melanocyte functions. Aim and Objectives: This study examines the role of EDN1 (G5665T and T-1370G) and EDNRA (C + 70G and G-231A) polymorphisms as a risk factor for vitiligo, and evaluates the relationship between genotypes and clinical characteristics of vitiligo patients. Materials and Methods: We analyzed genotype/allele distributions of EDN1 and EDNRA polymorphisms in 100 patients with vitiligo and 185 healthy controls by real-time polymerase chain reaction. Results: There was no notable risk for vitiligo afflicted by studied polymorphisms. However, the presence of EDNRA +70 variant G allele was found to be related with decreased risk for development of generalized type of vitiligo (odds ratio [OR]: 0.42, 95% confidence interval [CI] = 0.21-0.86, pcorr = 0.03) and showed protective effect against associated diseases seen in vitiligo (OR: 0.49, 95% CI = 0.27-0.88, pcorr Haplotype analysis demonstrated a strong (disequilibrium coefficient = 0.73, r²= 0.405) linkage disequilibrium between EDN1 G5665T and T-1370G polymorphisms. The EDN1 5665/-1330 TT haplotype was over represented significantly in controls than in patients (P = 0.04). Conclusion: The studied polymorphisms do not seem to be a major risk for vitiligo. Haplotype analysis denoting protective effects against vitiligo may indicate an indirect interaction in the course of vitiligo. In addition, EDNRA + 70 polymorphism is protective against generalized type of vitiligo and associated diseases.
- Subjects
VITILIGO; CHI-squared test; ENDOTHELINS; GENETIC polymorphisms; INFLAMMATION; RESEARCH funding; STATISTICS; DATA analysis; DATA analysis software; GENETICS
- Publication
Indian Journal of Dermatology, 2016, Vol 61, Issue 1, p116
- ISSN
0019-5154
- Publication type
Article
- DOI
10.4103/0019-5154.174076