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- Title
Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours.
- Authors
SAKAMOTO, K.; ONO, T.; NAKAMURA, Y.; HARADA, H.; NAKASHIMA, T.
- Abstract
Objectives: This study aimed to clarify the significance of cluster of differentiation 9 glycoprotein gene expression in human parotid gland tumours. Methods: We retrospectively analysed immunohistochemical staining for cluster of differentiation 9 glycoprotein in parotid gland tumours. Results: Cluster of differentiation 9 glycoprotein was consistently detected in the normal parotid gland. Regarding benign parotid gland tumours, cluster of differentiation 9 glycoprotein was present in 13 of 18 pleomorphic adenomas, in allWarthin tumours tested (21/21) and in all cases of basal cell adenoma tested ( four of four). In contrast, positive staining for cluster of differentiation 9 glycoprotein was less often observed in malignant parotid tumours. Cluster of differentiation 9 glycoprotein was present in 11 of 14 mucoepidermoid carcinomas, in two of five acinic cell carcinomas and in two of five adenoid cystic carcinomas. Conclusions: There was a statistically significantly reduced expression of cluster of differentiation 9 glycoprotein in malignant parotid gland tumours, compared with benign parotid gland tumours (p , 0.05). These results suggest that a low level of cluster of differentiation 9 glycoprotein expression in parotid gland tumours may be associated with malignancy.
- Subjects
LABYRINTHINE fistula; SURGERY; CHOLESTEATOMA; OTITIS media; THERAPEUTICS
- Publication
Journal of Laryngology & Otology, 2009, Vol 123, Issue S1, p58
- ISSN
0022-2151
- Publication type
Article
- DOI
10.1017/S0022215109005106