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- Title
The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers.
- Authors
Gehring, U.; de Jongste, J. C.; Kerkhof, M.; Oldewening, M.; Postma, D.; van Strien, R. T.; Wijga, A. H.; Willers, S. M.; Wolse, A.; Gerritsen, J.; Smit, H. A.; Brunekreef, B.
- Abstract
To cite this article: Gehring U, de Jongste JC, Kerkhof M, Oldewening M, Postma D, van Strien RT, Wijga AH, Willers SM, Wolse A, Gerritsen J, Smit HA, Brunekreef B. The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers. Allergy 2012; 67: 248-256. Abstract Background: Exposure to high levels of house dust mite (HDM) allergens is associated with the development of allergic sensitization to HDM, a risk factor for the development of asthma, rhinitis, and allergic dermatitis. We studied the effect of an early intervention with mite-impermeable mattress covers on HDM allergen levels and the development of asthma and mite allergy throughout the first 8 years of life. Methods: High-risk children (allergic mother) were prenatally recruited and randomly allocated to two groups receiving mite allergen-impermeable ( n = 416) and placebo mattress covers ( n = 394) or no intervention ( n = 472). Asthma and allergies were assessed yearly by questionnaire. Specific immunoglobulin E and bronchial hyper-responsiveness were measured at the age of 8 years. Mattress dust samples collected at different time points were analyzed for HDM allergens. Results: At the age of 8 years, levels of HDM allergen Der f1 but not Der p1 were lower in the active than the placebo mattress cover group. In repeated measures analyses, we found a temporary decreased risk of asthma symptoms at the age of 2 years in the intervention group compared to the placebo group and a temporary association between higher HDM allergen exposure at the age of 3 months and more asthma symptoms. Conclusion: Early intervention with mite-impermeable mattress covers is successful in reducing exposure to Der f1; it only temporarily reduces the risk of asthma symptoms and does not reduce the risk of hay fever, eczema, and allergic sensitization.
- Subjects
RESPIRATORY allergy; IMMUNOLOGIC diseases; SKIN inflammation; ALLERGIC rhinitis; ALLERGENS; MATTRESS covers
- Publication
Allergy, 2012, Vol 67, Issue 2, p248
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/j.1398-9995.2011.02739.x