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- Title
Fatty Acids and Their Lipogenic Enzymes in Anorexia Nervosa Clinical Subtypes.
- Authors
Nguyen, Nhien; Woodside, D. Blake; Lam, Eileen; Quehenberger, Oswald; German, J. Bruce; Shih, Pei-an Betty
- Abstract
Disordered eating behavior differs between the restricting subtype (AN-R) and the binging and purging subtype (AN-BP) of anorexia nervosa (AN). Yet, little is known about how these differences impact fatty acid (FA) dysregulation in AN. To address this question, we analyzed 26 FAs and 7 FA lipogenic enzymes (4 desaturases and 3 elongases) in 96 women: 25 AN-R, 25 AN-BP, and 46 healthy control women. Our goal was to assess subtype-specific patterns. Lauric acid was significantly higher in AN-BP than in AN-R at the fasting timepoint (p = 0.038) and displayed significantly different postprandial changes 2 h after eating. AN-R displayed significantly higher levels of n-3 alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid (EPA), docosapentaenoic acid, and n-6 linoleic acid and gamma-linolenic acid compared to controls. AN-BP showed elevated EPA and saturated lauric acid compared to controls. Higher EPA was associated with elevated anxiety in AN-R (p = 0.035) but was linked to lower anxiety in AN-BP (p = 0.043). These findings suggest distinct disordered eating behaviors in AN subtypes contribute to lipid dysregulation and eating disorder comorbidities. A personalized dietary intervention may improve lipid dysregulation and enhance treatment effectiveness for AN.
- Subjects
ANOREXIA nervosa; FATTY acids; LAURIC acid; DIETARY patterns; ALPHA-linolenic acid; EICOSAPENTAENOIC acid
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 10, p5516
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25105516