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- Title
Fidgety movements in infants born very preterm: predictive value for cerebral palsy in a clinical multicentre setting.
- Authors
Datta, Alexandre N; Furrer, Mark A; Bernhardt, Iris; Hüppi, Petra S; Borradori‐Tolsa, Cristina; Bucher, Hans Ulrich; Latal, Beatrice; Grunt, Sebastian; Natalucci, Giancarlo; Pfister, Riccardo E.; Menache, Caroline; Quero, Christine Uehlinger; Nelle, Mathias; Steinlin, Maja; Adams, Mark; Hüppi, Petra S; Borradori-Tolsa, Cristina; GM Group
- Abstract
<bold>Aim: </bold>This study assessed predictive values of fidgety movement assessment (FMA) in a large sample of infants born very preterm for developmental abnormalities, in particular for cerebral palsy (CP) at 2 years in an everyday clinical setting.<bold>Method: </bold>This is a multicentre study of infants born preterm with gestational age lower than 32.0 weeks. FMA was performed at 3 months corrected age; neurodevelopment (Bayley Scales of Infant Development, 2nd edition) and neurological abnormalities were assessed at 2 years. Predictive values of FMA for the development of CP were calculated and combined with abnormalities at cerebral ultrasound.<bold>Results: </bold>Five hundred and thirty-five infants (gestational age 28.2wks [standard deviation 1.3wks]) were included. Eighty-one percent showed normal fidgety movements and 19% atypical (82 absent, 21 abnormal) fidgety movements. Absent fidgety movements predicted CP at 2 years with an odds ratio (OR) of 8.9 (95% confidence interval [CI] 4.1-17.0), a combination of atypical fidgety movements and major brain lesion on cerebral ultrasound predicted it with an OR of 17.8 (95% CI 5.2-61.6). Mean mental developmental index of infants with absent fidgety movements was significantly lower (p=0.012) than with normal fidgety movements.<bold>Interpretation: </bold>Detection of infants at risk for later CP through FMA was good, but less robust when performed in a routine clinical setting; prediction improved when combined with neonatal cerebral ultrasound.
- Subjects
SWITZERLAND; FIDGETING; MOVEMENT disorders; CEREBRAL palsy; SPASTIC paralysis; NEUROLOGICAL disorders; DISEASE risk factors; CHILD development; COMPARATIVE studies; PREMATURE infants; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PROGNOSIS; RESEARCH; ULTRASONIC encephalography; EVALUATION research; BODY movement; DIAGNOSIS
- Publication
Developmental Medicine & Child Neurology, 2017, Vol 59, Issue 6, p618
- ISSN
0012-1622
- Publication type
journal article
- DOI
10.1111/dmcn.13386