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- Title
ROLE OF MITOCHONDRIAL NITRIC OXIDE AND REACTIVE OXYGEN SPECIES IN RAT KIDNEY DURING DIABETES.
- Authors
Esquivel-Gutiérrez, Edgar; Noriega-Cisneros, Ruth; Clemente-Guerrero, Mónica; Caudillo-Noriega, Evangelina; Gutiérrez-Pérez, Areli; Calderón-Cortés, Elizabeth; Cortés-Rojo, Christian; Manzo-Ávalos, Salvador; Saavedra-Molina, Alfredo
- Abstract
Diabetes mellitus (DM) is a heterogeneous metabolic disorder characterized by hyperglycemia resulting from defective insulin secretion, resistance to insulin action or both. Oxidative damage due to hyperglycemia contributes to the microvascular pathology of diabetes that occurs in the renal glomerulus. The long-term complications in DM include diabetic nephropathy. Veelken et al. (2000) tested that renal vasodilatation mediated by nitric oxide (NO) is due to endothelial constitutive nitric oxide synthase (eNOS) activity and contributed to hyperfiltration and renal injury in diabetic rats. NO is an important factor in the etiology and pathogenesis in early diabetic nephropathy of rats. Thereafter, our laboratory is interesting in the role of mitochondrial NO (mtNO) during diabetes in kidney of streptozotocin (STZ)-induced. diabetic rats. Our results showed that increased mtNO production is markedly high at the seven days after a single injection of STZ. We observed also at the end of seven and sixteen weeks less mtNO production, perhaps the mtNO is combined with superoxide anion to produce peroxynitrite, because the biological effects of NO are significantly mediated through S-nitrosylation. In DM, oxidative stress seems mainly to be due to an increased production of free radical and/or a sharp reduction of antioxidant defense. Therefore, oxidative and nitrosative stress plays a central role in diabetic renal tissue damage.
- Subjects
MITOCHONDRIA; NITRIC oxide; LABORATORY rats; DIABETES; KIDNEYS
- Publication
FASEB Journal, 2007, Vol 21, Issue 5, pA668
- ISSN
0892-6638
- Publication type
Article