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- Title
Prognostic significance of diabetes mellitus in locally advanced non-small cell lung cancer.
- Authors
Hisao Imai; Kyoichi Kaira; Keita Mori; Akira Ono; Hiroaki Akamatsu; Shunichi Matsumoto; Tetsuhiko Taira; Hirotsugu Kenmotsu; Hideyuki Harada; Tateaki Naito; Haruyasu Murakami; Masahiro Endo; Takashi Nakajima; Masanobu Yamada; Toshiaki Takahashi; Imai, Hisao; Kaira, Kyoichi; Mori, Keita; Ono, Akira; Akamatsu, Hiroaki
- Abstract
<bold>Background: </bold>To investigate the prognostic significance of patient characteristics and clinical laboratory test results in locally advanced non-small cell lung cancer (NSCLC), and in particular the impact of diabetes mellitus (DM) on the survival of patients who underwent chemoradiotherapy.<bold>Methods: </bold>We retrospectively reviewed 159 patients with locally advanced NSCLC with a focus on DM and other potential prognostic factors, using the log-rank test, and univariate and multivariate analyses to assess their association with survival.<bold>Result: </bold>Five significant prognostic factors were identified in univariate analysis: stage (p < 0.001), DM (p = 0.04), hemoglobin levels (p = 0.003), serum albumin (p <0.001) and lactate dehydrogenase (LDH) levels (p = 0.01). Furthermore, among the factors tested using Fisher's exact test and the Wilcoxon rank sum test, gender (p = 0.019) and plasma glucose level (p <0.001) were found to have prognostic significance. Multivariate analysis showed that stage, DM, serum albumin and LDH levels were independent prognostic factors for survival (p = 0.007, p = 0.024, p = 0.007 and p = 0.005, respectively).<bold>Conclusions: </bold>The presence of DM at the time of diagnosis was identified as an independent and significant prognostic factor for predicting negative outcome in locally advanced NSCLC patients.
- Subjects
DIABETES; NON-small-cell lung carcinoma; CANCER radiotherapy; CANCER chemotherapy; LACTATE dehydrogenase; HEMOGLOBINS; PROGNOSIS
- Publication
BMC Cancer, 2015, Vol 15, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-015-2012-4