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- Title
Enhanced Transport of Nandrolone Decanoate Drug by Human Serum Albumin in Presence of [BMIM]PF<sub>6</sub> and [BMIM]BF<sub>4</sub>.
- Authors
Yasseen, Zeyad J.; Saadeh, Salman M.; Shawish, Hazem M. Abu
- Abstract
The interaction of nandrolone decanoate drug dissolved in (2%) [BMIM]BF4 or [BMIM]PF6 with human serum albumin (HSA) at different temperatures in the range of 285-310 K was examined by fluorescence quenching. Stern-Volmer equation and its modifi d form were used to determine the interaction parameters K and n. The results revealed that binding affi ties of HSA for nandrolone decanoate drug in 2% [BMIM]BF4 or [BMIM]PF6 are in the order of 105 M-1 and the number of bound drug molecules per HSA macromolecule are approximated to 1 at all temperatures studied. The thermodynamic parameters: free energy change (∆Go), enthalpy change (∆Ho) and entropy change (∆So) for HAS-nandrolone decanoate/ionic liquid were calculated according to van't Hoff equation. Data analysis indicated that both electrostatic interactions and hydrophobic ineractions played important roles in the interaction of nandrolone decanoate drug with HSA.
- Subjects
NANDROLONE; SERUM albumin; DRUG interactions; ELECTROSTATIC interaction; HYDROPHOBIC interactions
- Publication
Acta Chimica Slovenica, 2018, Vol 65, Issue 3, p638
- ISSN
1318-0207
- Publication type
Article
- DOI
10.17344/acsi.2018.4301