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- Title
Spermidine in dementia: Relation to age and memory performance.
- Authors
Pekar, Thomas; Wendzel, Aribert; Flak, Walter; Kremer, Alexandra; Pauschenwein-Frantsich, Susanne; Gschaider, Anna; Wantke, Felix; Jarisch, Reinhart
- Abstract
Summary: Previous studies have highlighted that spermidine has the ability to trigger the important process of dissolving amyloid-beta plaques by autophagy. This manuscript focuses on the correlation of serum spermidine levels between age and between performance in mini-mental state examinations. It will serve as a premise for an ongoing multicentric placebo-controlled study, which focuses on the effect of oral spermidine supplementation on memory performance. Memory tests were carried out on 80 subjects aged 60–96 years old in 6 nursing homes in Styria. Blood samples were taken for the determination of spermidine concentration. The results showed a significant correlation between the spermidine concentration and the mini-mental state examination score (p = 0.025). On the basis of the dependence demonstrated it can be concluded that spermidine might be suitable as a biomarker for the diagnosis of neurocognitive changes (senile dementia or Alzheimer's disease).
- Subjects
STYRIA (Austria); AGE factors in memory; SPERMIDINE; SENILE dementia; ALZHEIMER'S disease; MEMORY testing; MINI-Mental State Examination
- Publication
Wiener Klinische Wochenschrift, 2020, Vol 132, Issue 1/2, p42
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-019-01588-7