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- Title
Abnormal carnitine metabolism in hemodialysis patients on different anticoagulants.
- Authors
Sekiguchi, Kie; Abe, Takaya; Shiomi, Ei; Ikarashi, Daiki; Matsuura, Tomohiko; Maekawa, Shigekatsu; Kato, Renpei; Kanehira, Mitsugu; Takata, Ryo; Sugimura, Jun; Sekiguchi, Takashi; Obara, Wataru
- Abstract
Introduction: We aimed to determine whether unfractionated heparin (UH) and low molecular weight heparin (LH) contribute to aberrant carnitine metabolism in patients receiving hemodialysis. Methods: The rate of increase in serum free fatty acids (FFAs) and the ratio of acylcarnitine to free carnitine (AC/FC) from before to after hemodialysis were determined in patients receiving UH and LH. Additionally, the effect of switching patients to UH from LH was examined. Results: AC/FC was significantly higher in the UH group. In addition, serum FFAs in that group increased to 0.825 ± 0.270 after dialysis from 0.172 ± 0.160 before dialysis, showing a positive correlation with AC/FC. Furthermore, AC/FC was observed to be significantly higher in patients who were switched to UH from LH at 3 months after the change. Conclusion: Compared with UH, LH has a lesser effect on lipid metabolism, suggesting that it also has a lesser effect on carnitine metabolism.
- Subjects
LOW-molecular-weight heparin; HEMODIALYSIS patients; CARNITINE; FREE fatty acids; ANTICOAGULANTS
- Publication
Therapeutic Apheresis & Dialysis, 2024, Vol 28, Issue 3, p364
- ISSN
1744-9979
- Publication type
Article
- DOI
10.1111/1744-9987.14096