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- Title
Cytochrome c is released from coupled mitochondria of yeast en route to acetic acid-induced programmed cell death and can work as an electron donor and a ROS scavenger
- Authors
Giannattasio, Sergio; Atlante, Anna; Antonacci, Lucia; Guaragnella, Nicoletta; Lattanzio, Paolo; Passarella, Salvatore; Marra, Ersilia
- Abstract
Abstract: To gain insight into the processes by which acetic acid-induced programmed cell death (AA-PCD) takes place in yeast, we investigated both cytochrome c release from yeast mitochondria and mitochondrial coupling over the time course of AA-PCD. We show that the majority of cytochrome c release occurs early in AA-PCD from intact coupled mitochondria which undergo only gradual impairment. The released cytochrome c can be reduced both by ascorbate and by superoxide anion and in turn be oxidized via cytochrome c oxidase, thus working both as a ROS scavenger and a respiratory substrate. Late in AA-PCD, the released cytochrome c is degraded.
- Subjects
CYTOCHROME c; CELL death; MITOCHONDRIA; YEAST
- Publication
FEBS Letters, 2008, Vol 582, Issue 10, p1519
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.03.048