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- Title
PKCζII is a target for degradation through the tumour suppressor protein pVHL
- Authors
Iturrioz, Xavier; Parker, Peter J.
- Abstract
Abstract: PKCζII is a rapidly degraded variant of PKCζ that suppresses epithelial cell polarisation. It is shown here that PKCζII is a target for the E3 ligase and tumour suppressor Von Hippel-Lindau protein (pVHL). Deletion studies demonstrate that the C-terminal region is required for the pVHL and proteasome dependent turnover of PKCζII, however it is the N-terminal PB1 domain of PKCζII that is required for pVHL complex formation. Reciprocal deletion studies define the pVHL effector domain as the dominant PKCζII binding site. The results indicate that pVHL recruits PKCζII via its PB1 domain and causes ubiquitination and degradation via the distal C-terminus of PKCζII.
- Subjects
TUMORS; EPITHELIAL cells; EPITHELIUM; CELLS
- Publication
FEBS Letters, 2007, Vol 581, Issue 7, p1397
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.02.059