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- Title
Preparation and in vitro evaluation of Lu-iPSMA-RGD as a new heterobivalent radiopharmaceutical.
- Authors
Escudero-Castellanos, Alondra; Ocampo-García, Blanca; Ferro-Flores, Guillermina; Isaac-Olivé, Keila; Santos-Cuevas, Clara; Olmos-Ortiz, Andrea; García-Quiroz, Janice; García-Becerra, Rocío; Díaz, Lorenza
- Abstract
This study aimed to synthesize a new Lu-iPSMA-RGD heterobivalent radiopharmaceutical, as well as to assess the in vitro radiopharmaceutical potential to target cancer cells overexpressing PSMA and α(v) β(3) integrins. The radiotracer prepared with a radiochemical purity of 98.8 ± 1.0% showed stability in human serum, specific recognition with suitable affinity to PSMA and α(v)β(3) integrins, and capability to inhibit cancer cell proliferation and VEGF signaling (antiangiogenic effect). Results warrant further preclinical studies to establish the Lu-iPSMA-RGD potential as a dual therapeutic radiopharmaceutical.
- Subjects
RADIOPHARMACEUTICALS; RADIOPHARMACOLOGY; NUCLEAR medicine; METASTASIS; CANCER invasiveness
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2017, Vol 314, Issue 3, p2201
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-017-5555-9