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- Title
Association of the matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of coronavirus disease 2019 (COVID-19); implications of contribution for development of neurological symptoms in the COVID-19 patients.
- Authors
Ramezani, Samaneh; Ezzatifar, Fatemeh; Hojjatipour, Tahereh; Hemmatzadeh, Maryam; Shabgah, Arezoo Gowhari; Navashenaq, Jamshid Gholizadeh; Aslani, Saeed; Shomali, Navid; Arabi, Mohsen; Babaie, Farhad; Jadidi-Niaragh, Farhad; Hosseinzadeh, Ramin; Feizisani, Fahimeh; Khodayar, Sara; Safari, Roghaiyeh; Mohammadi, Hamed
- Abstract
Background: Seemingly, the Matrix metalloproteinases (MMPs) play a role in the etiopathogenesis of coronavirus disease 2019 (COVID-19). Here in this study, we determined the association of MMP9 rs3918242, MMP3 rs3025058, and MMP2 rs243865 polymorphisms with the risk of COVID-19, especially in those with neurological syndrome (NS). Methods: We enrolled 500 patients with COVID-19 and 500 healthy individuals. To genotype the target SNPs, the Real-time allelic discrimination technique was used. To determine serum levels of MMPs, Enzyme-linked immunosorbent assay (ELISA) was exerted. Results: The MMP9 gene rs3918242 and MMP3 gene rs3025058 SNP were significantly associated with increased COVID-19 risk and susceptibility to COVID-19 with NS. The serum level of MMP-9 and MMP-3 was significantly higher in COVID-19 cases compared with the healthy controls. Serum MMP-9 and MMP-3 levels were also higher in COVID-19 subjects with NS in comparison to the healthy controls. The polymorphisms in MMP genes were not associated with serum level of MMPs. Conclusion: MMP9 and MMP3 gene polymorphisms increases the susceptibility to COVID-19 as well as COVID-19 with neurologic syndrome, but they probably have no role in the regulation of serum MMP-9 and MMP-3 levels.
- Subjects
COVID-19; MATRIX metalloproteinases; GENETIC polymorphisms; GENE families; COVID-19 pandemic
- Publication
Molecular Biology Reports, 2023, Vol 50, Issue 1, p173
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-022-07907-y