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- Title
A retrospective international study on primary extranodal marginal zone lymphoma of the lung (BALT lymphoma) on behalf of International Extranodal Lymphoma Study Group (IELSG).
- Authors
Sammassimo, Simona; Pruneri, Giancarlo; Andreola, Giovanna; Montoro, Juan; Steffanoni, Sara; Nowakowski, Grzegorz S.; Gandini, Sara; Negri, Mara; Habermann, Thomas M.; Raderer, Markus; Li, Zhi‐Ming; Zinzani, Pier Luigi; Adam, Patrick; Zucca, Emanuele; Martinelli, Giovanni
- Abstract
Primary lymphoma of the lung is a rare entity. Clinical features, optimal treatment, role of surgery and outcomes are not well defined, and the follow-up is variable in published data. Clinical data of 205 patients who were confirmed to have bronchus mucosa-associated lymphoid tissue lymphoma from December 1986 to December 2011 in 17 different centres worldwide were evaluated. Fifty-five per cent of the patients were female. The median age at diagnosis was 62 (range 28-88) years. Only 9% had a history of exposure to toxic substances, while about 45% of the patients had a history of smoking. Ten per cent of the patients had autoimmune disease at presentation, and 19% patients had a reported preexisting lung disease. Treatment modalities included surgery alone in 63 patients (30%), radiotherapy in 3 (2%), antibiotics in 1 (1%) and systemic treatment in 128 (62%). Patients receiving a local approach, mainly surgical resection, experienced significantly improved progression-free survival (p = 0.003) versus those receiving a systemic treatment. There were no other significant differences among treatment modalities. The survival data confirm the indolent nature of the disease. Local therapy (surgery or radiotherapy) results in long-term disease-free survival for patients with localized disease. Systemic treatment, including alkylating-containing regimens, can be reserved to patients in relapse after incomplete surgical excision or for patients with advanced disease. Copyright © 2015 John Wiley & Sons, Ltd.
- Subjects
TREATMENT of lung tumors; B cell lymphoma; COMPARATIVE studies; LONGITUDINAL method; LUNG tumors; RESEARCH methodology; MEDICAL cooperation; PROGNOSIS; RESEARCH; SURVIVAL; EVALUATION research; RETROSPECTIVE studies; TUMOR treatment
- Publication
Hematological Oncology, 2016, Vol 34, Issue 4, p177
- ISSN
0278-0232
- Publication type
journal article
- DOI
10.1002/hon.2243