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- Title
The incidence, risk factors, and outcomes of acute kidney injury in patients with pyogenic liver abscesses.
- Authors
Yun, Seong; Jeon, Dae-Hong; Kim, Min; Bae, Eun; Cho, Hyun; Chang, Se-Ho; Park, Dong
- Abstract
Background: Acute kidney injury (AKI) can occur in various infectious conditions. Liver abscess is relatively rare, but can lead to sepsis and/or other severe complications. Few studies of AKI in patients with a liver abscess have been conducted. Therefore, we analyzed the clinical and laboratory data of AKI in patients with a liver abscess. Methods: We retrospectively reviewed the medical records of patients who were diagnosed with a liver abscess from January 2000 to March 2013. The study included 404 patients with a liver abscess confirmed by clinical presentation and computed tomography. Results: AKI occurred in 137 patients (34 %). As per RIFLE classification, renal injury was graded as either at risk of renal dysfunction (35.8 %), renal injury (47.4 %), and renal failure (16.5 %). AKI occurred more frequently in males and patients with liver cirrhosis ( P < 0.001 and P = 0.005). Patients with AKI had lower serum albumin and higher AST and ALT levels than did patients without AKI. Bacteria were frequently isolated in AKI patients from blood culture and liver abscess aspirates ( P < 0.001 and P = 0.007). The occurrence of septic shock was positively correlated with AKI ( P = 0.002) and AKI was more frequent in patients with chronic kidney disease ( P = 0.04). Higher mortality was observed in CKD patients accompanied by AKI ( P < 0.001). Three patients with AKI underwent hemodialysis; two patients who had initially normal renal function completely recovered whereas one CKD patient progressed to ESRD, requiring maintenance hemodialysis. Conclusion: AKI is relatively common in patients with liver abscess. Physicians should therefore attempt to prevent, detect, and manage AKI early in patients with liver abscess.
- Subjects
DISEASE incidence; ACUTE kidney failure; PYOGENIC liver abscess; MEDICAL records; HEALTH outcome assessment; RETROSPECTIVE studies; COMPUTED tomography; PATIENTS; DIAGNOSIS
- Publication
Clinical & Experimental Nephrology, 2015, Vol 19, Issue 3, p458
- ISSN
1342-1751
- Publication type
Article
- DOI
10.1007/s10157-014-1016-8