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- Title
Effects of pioglitazone on the differentiation and inflammation in vitiligo keratinocytes.
- Authors
Bastonini, E.; Kovacs, D.; Briganti, S.; Ottaviani, M.; D'Arino, A.; Migliano, E.; Pacifico, A.; Iacovelli, P.; Picardo, M.
- Abstract
This article discusses the effects of pioglitazone, a medication used to treat chronic inflammatory skin diseases, on vitiligo keratinocytes. Vitiligo is a skin disorder characterized by the loss of melanocytes, and previous research has shown defects in the skin barrier and inflammation in vitiligo-affected skin. The study found that pioglitazone treatment improved keratinocyte differentiation, skin barrier assembly, and reduced inflammation in vitiligo keratinocytes. These findings suggest that pioglitazone may be a potential therapeutic option for vitiligo by preserving and reinforcing the skin barrier and reducing inflammation.
- Subjects
VITILIGO; PIOGLITAZONE; KERATINOCYTES; MOLECULAR biology; TRANSCRIPTION factors; INFLAMMATION
- Publication
Journal of the European Academy of Dermatology & Venereology, 2024, Vol 38, Issue 7, pe573
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/jdv.19754