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- Title
Which factors can aid clinicians to identify a risk of pain during the following month in patients with bone metastases? A longitudinal analyses.
- Authors
Habberstad, Ragnhild; Hjermstad, M. J.; Brunelli, C.; Kaasa, S.; Bennett, M. I.; Pardon, K.; Klepstad, P.
- Abstract
<bold>Purpose: </bold>Explore clinical factors associated with higher pain intensity and future pain in patients with bone metastases to identify patients who can benefit from closer follow-up or pain-modifying interventions.<bold>Methods: </bold>This is a secondary analysis of 606 patients with bone metastases included in a multicenter longitudinal study. The dependent variables were "average pain" and "worst pain" in the last 24 h (0-10 NRS). Twenty independent variables with potential association to pain intensity were selected based on previous literature. Cross-sectional analyses were performed with multiple linear regression to explore factors associated with pain intensity at baseline. Longitudinal data were analyzed with a generalized equation models to explore current factors associated with pain intensity at the next visit in 1 month.<bold>Results: </bold>Current pain intensity (p < 0.001), sleep disturbances (p 0.01 and 0.006), drowsiness (p 0.003 and 0.033) and male gender (p 0.045 and 0.001) were associated with higher average and worst pain intensity in 1 month. In addition, breakthrough pain was related to higher worst pain intensity (p 0.003) in 1 month. The same variables were also associated with higher average pain intensity at baseline.<bold>Conclusion: </bold>Higher current pain intensity, sleep disturbances, drowsiness, male gender, and breakthrough pain are factors associated with higher pain intensity in patients with bone metastases at the next follow-up in 1 month. These factors should be assessed in clinical practice and may aid clinicians in identifying patients that can benefit from closer follow-up or interventions to prevent lack of future pain control. TRIAL REGISTRATION IN CLINICALTRIALS.GOV : NCT01362816.
- Subjects
BONE metastasis; PAIN; PAIN management; BONE tumors; LONGITUDINAL method; RESEARCH funding; PAIN measurement; CROSS-sectional method; SEVERITY of illness index; DISEASE complications
- Publication
Supportive Care in Cancer, 2019, Vol 27, Issue 4, p1335
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-018-4405-9