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- Title
Increased levels of SLP-2 correlate with poor prognosis in gastric cancer.
- Authors
Liu, Dongning; Zhang, Lei; Shen, Zhiyong; Tan, Fei; Hu, Yanfeng; Yu, Jiang; Li, Guoxin
- Abstract
Background: Stomatin-like protein 2 (SLP-2) is a member of the highly conserved stomatin protein family whose homologues span from Archaea to humans and include stomatin, SLP-1, and SLP-3. Several studies have indicated that overexpression of SLP-2 is strongly associated with adhesion and migration in several human cancers. The aim of the present study was to evaluate SLP-2 expression at the mRNA and protein level in patients with gastric cancer (GC) and to examine the relationships between SLP-2 expression, clinicopathological features, and prognosis. Methods: We investigated SLP-2 expression in primary GC and paired normal gastric tissue by real-time PCR (RT-PCR; n = 16) and Western blot analysis ( n = 32). Additionally, we performed immunohistochemistry (IHC) on 113 paraffin-embedded GC specimens, 30 matched normal specimens, and 30 paired metastatic lymph node samples. Results: SLP-2 is overexpressed in GC compared with the adjacent normal gastric epithelium ( p < 0.001), and high-level SLP-2 expression is significantly correlated with the depth of invasion, lymph node metastasis, distant metastasis, and American Joint Committee on Cancer (AJCC) stage. Furthermore, elevated SLP-2 expression is an independent prognostic factor in multivariate analysis using the Cox regression model ( p = 0.005). Conclusions: Overexpression of SLP-2 may contribute to the progression and poor prognosis of GC.
- Subjects
GASTROINTESTINAL cancer; CANCER patients; METASTASIS; IMMUNOHISTOCHEMISTRY; LYMPH nodes
- Publication
Gastric Cancer, 2013, Vol 16, Issue 4, p498
- ISSN
1436-3291
- Publication type
Article
- DOI
10.1007/s10120-013-0232-3