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- Title
Na 2 S-Mediated One-Pot Selective Deoxygenation of α-Hydroxyl Carbonyl Compounds including Natural Products.
- Authors
Xu, Xiaobo; Yan, Leyu; Zhang, Zhi-Kai; Lu, Bingqing; Guo, Zhuangwen; Chen, Mengyue; Cao, Zhong-Yan
- Abstract
A practical method for the deoxygenation of α-hydroxyl carbonyl compounds under mild reaction conditions is reported here. The use of cheap and easy-to-handle Na2S·9H2O as the reductant in the presence of PPh3 and N-chlorosuccinimide (NCS) enables the selective dehydroxylation of α-hydroxyl carbonyl compounds, including ketones, esters, amides, imides and nitrile groups. The synthetic utility is demonstrated by the late-stage deoxygenation of bioactive molecule and complex natural products.
- Subjects
CARBONYL compounds; NATURAL products; DEOXYGENATION; NITRILIMINES; KETONES; BIMETALLIC catalysts
- Publication
Molecules, 2022, Vol 27, Issue 15, p4675
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27154675