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- Title
Management of pregnancy in a patient with congenital hyperinsulinism treated with association of diazoxide/calcium channel blocker.
- Authors
Lemaitre, Madleen; Douillard, Claire; Froguel, Philippe; Bonnefond, Amélie; Vambergue, Anne
- Abstract
We present here a case of management of two pregnancies in the same patient with congenital hyperinsulinism, treated by an association of diazoxide/calcium channel blocker. Treatment was stopped but the patient developed severe hypoglycemia. A list of 41 genes causing monogenic hyperinsulinism (or diabetes) including I ABCC8 i , I KCNJ11 i , I HADH i , I GCK i was investigated using whole-exome sequencing of patient DNA (via Agilent SureSelect 71 Mb v5 in combination with Illumina sequencing on the HiSeq4000 system).
- Subjects
CALCIUM antagonists; HYPERINSULINISM; PREGNANCY
- Publication
Acta Diabetologica, 2022, Vol 59, Issue 8, p1117
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-022-01898-9