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- Title
Effects of β-HPV on DNA damage response pathways to drive carcinogenesis: a review.
- Authors
Tahseen, Danyal; Rady, Peter L.; Tyring, Stephen K.
- Abstract
The DDR is a complex signaling network responsible for the preservation of genomic integrity. Beta human papillomaviruses (β-HPVs) are able to destabilize the host genome by attenuating the DDR machinery at the molecular scale following expression of the oncogenes E6 and E7. In the event of β-HPV infection, the E6- and E7-mediated inhibition of the DDR enhances the oncogenicity of UV-induced mutations to enable carcinogenesis in an otherwise immunocompetent host, marking an important mechanistic divergence from the alpha genus of HPVs. In this review, we summarize recent updates to build upon the 'hit-and-run' hypothesis of β-HPV pathomechanism and highlight strain-dependent variations. Simultaneously, we illuminate points within the β-HPV–DDR interface that may unravel new insights for HPV viral genetics, genus-specific mechanistic models, and developments in targeted molecular therapy of β-HPV-related cancers.
- Subjects
DNA repair; DNA damage; VIRAL genetics; ONCOGENES; PAPILLOMAVIRUS diseases; CARCINOGENESIS; PAPILLOMAVIRUSES; GENOMES
- Publication
Virus Genes, 2021, Vol 57, Issue 1, p23
- ISSN
0920-8569
- Publication type
Article
- DOI
10.1007/s11262-020-01813-w