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- Title
Effect of Black-Currant Extract on Negative Lens-Induced Ocular Growth in Chicks.
- Authors
Iida, Hiroyuki; Nakamura, Yuko; Matsumoto, Hitoshi; Takeuchi, Yasuo; Harano, Shokichi; Ishihara, Mamoru; Katsumi, Osamu
- Abstract
Aim: To evaluate the effects of orally administered black-currant (BC) extract on the enlargement of globe component dimensions induced in chicks by wearing negative lenses. Methods: Negative lenses (-8 D) were worn on the right eyes by 8-day-old chicks, and their fellow eyes acted as controls. BC extract and distilled water (vehicle control) were orally administered once a day for 3 days. To confirm the effect of BC anthocyanins (BCAs), they were intravenously administered once a day for 3 days. Dimensions of globe components of right eyes and fellow eyes were measured with an A-scan ultrasound instrument on the third day (day 4) after placement of the negative lenses. Results: Orally administered BC extract significantly inhibited enlargement of vitreous-chamber depth, axial and ocular lengths in a dose-dependent manner when compared to controls. Intravenously administered BCAs also inhibited elongation of vitreous-chamber depth and axial length when compared to controls. Conclusions: This is the first evidence that BC extract and BCAs could inhibit enlargement of globe component dimensions in a negative lens-induced chick myopia model. Copyright © 2010 S. Karger AG, Basel
- Subjects
EUROPEAN black currant; PLANT extracts; LENSES; EYE diseases; DRUG administration; ANTHOCYANINS; MYOPIA treatment; CHICKS; DISEASES
- Publication
Ophthalmic Research, 2010, Vol 44, Issue 4, p242
- ISSN
0030-3747
- Publication type
Article
- DOI
10.1159/000313559